ISCB Course 2014

Novel approaches to multiple test problems, with applications to adaptive designs and dose finding

Budapest, 27-28 November 2014

 

Frank Bretz (Global Head of the Statistical Methodology Group, Novartis) and Franz König (Associate Professor, Section of Medical Statistics, Medical University of Vienna) are to hold a course titled Novel approaches to multiple test problems, with applications to adaptive designs and dose finding.

The issue of multiplicity often arises in the design and analysis of clinical trials. Common multiple test problems include comparing several doses with a control, assessing the benefit of a new treatment for more than one endpoint, combined non-inferiority and superiority testing, or any combination thereof. One particular application arises in confirmatory adaptive design trials, when multiplicity adjustments must be made to account for adaptations made during the study. Another application arises in dose finding studies, where multiplicity due to model uncertainty has to be addressed. This 1.5-day course will begin with the introduction of the basic fundamentals of multiplicity methodology, and continue through novel methods and strategies for addressing multiplicity concerns. These techniques will be demonstrated with several case studies.

Please find the agenda along with the details of application here.